Cytotoxic and Proinflammatory CD8 T Lymphocytes Promote Development of Vulnerable Atherosclerotic Plaques in ApoE Mice
نویسندگان
چکیده
Ins sti it tute e of f f M Med d dic ic i a a al R R Rese ea earch, h, C C Cla lay yt yto on on, V V Victo or ori ia, A A Aus st stra ra alia a a # # # co cont ntri i ribu bute ted d d eq equa uall ll lly y Abstract: Background—Heart attacks and strokes, leading causes of deaths globally, arise from
منابع مشابه
Cytotoxic and proinflammatory CD8+ T lymphocytes promote development of vulnerable atherosclerotic plaques in apoE-deficient mice.
BACKGROUND Heart attacks and strokes, leading causes of deaths globally, arise from thrombotic occlusion of ruptured vulnerable atherosclerotic plaques characterized by abundant apoptosis, large necrotic cores derived from inefficient apoptotic cell clearance, thin fibrous caps, and focal inflammation. The genesis of apoptosis and necrotic cores in these vulnerable atherosclerotic plaques remai...
متن کاملInfluence of shear stress magnitude and direction on atherosclerotic plaque composition
The precise flow characteristics that promote different atherosclerotic plaque types remain unclear. We previously developed a blood flow-modifying cuff for ApoE-/- mice that induces the development of advanced plaques with vulnerable and stable features upstream and downstream of the cuff, respectively. Herein, we sought to test the hypothesis that changes in flow magnitude promote formation o...
متن کاملPrevalence of Foam Cells and Helper-T cells in Atherosclerotic Plaques of Korean Patients with Carotid Atheroma
BACKGROUND Inflammation and activation of immune cells have important roles in the pathogenesis of atherosclerosis. We analyzed the involvement of various immune cells in the pathogenesis of atherosclerosis. METHODS We investigated the presence of foam cells, lymphocytes and killer cells in 11 atherosclerotic plaque specimens removed from Korean patients who underwent carotid endoarterectomy....
متن کاملDeletion of L-Selectin Increases Atherosclerosis Development in ApoE−/− Mice
Atherosclerosis is an inflammatory disease characterized by accumulation of leukocytes in the arterial intima. Members of the selectin family of adhesion molecules are important mediators of leukocyte extravasation. However, it is unclear whether L-selectin (L-sel) is involved in the pathogenesis of atherosclerosis. In the present study, mice deficient in L-selectin (L-sel(-/-)) animals were cr...
متن کاملA critical function of Th17 proinflammatory cells in the development of atherosclerotic plaque in mice.
Considerable evidence supports that the CD4(+) T cell-mediated immune response contributes to the development of atherosclerotic plaque. However, the effects of Th17 cells on atherosclerosis are not thoroughly understood. In this study, we evaluated the production and function of Th17 and Th1 cells in atherosclerotic-susceptible ApoE(-/-) mice. We observed that the proportion of Th17 cells, as ...
متن کامل